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Han lupus susceptibility genes found in China

Number of visits: Date:2014-10-30 10:00:33

Erythematosus because of its high mortality rate, no cure means, the medical community has been called "chronic cancer." Ann Medical scientists through the study of thousands of patients with lupus found genes involved in the pathogenesis of variation. October 19, internationally renowned academic journal "Nature genetic" (Nature Genetics) online publishing this research.
Systemic lupus erythematosus is a common autoimmune diseases occur in women, especially women of childbearing age, can affect various body systems and organs, and ultimately induce renal failure, lupus encephalopathy and severe secondary infection, resulting in patients death. It is estimated that China has more than 100 million people in lupus patients.

It is understood, Anhui Medical genetics research team by the skin of more than 12,000 Han Systems Department Patients and healthy controls, and found that the five lupus susceptibility genes and identified four new susceptibility loci . The research on lupus warning, clinical diagnosis and drug development has an important meaning, marking the research on the disease susceptibility genes among the world's advanced level.

The project director, Anhui Medical University, Anhui Medical University, director of the Institute of Dermatology, Professor Zhang Xuejun introduction, researchers for more than 12,000 cases by patients and healthy control samples Han Chinese erythematosus, and found that the incidence of five and Han population closely related susceptibility genes ETS1, IKZF1, RASGRP3, SLC15A4 and TNIP1, and identified four new susceptibility loci; the study also verified the seven susceptibility genes found in Europeans also exists in Chinese Han population. The study first demonstrated by genetic studies of the pathogenesis of lupus genetic risk factors have the same and different susceptibility genes among different ethnic groups; the same time, the study is erythematosus genome-wide association analysis in the world today samples of the largest research projects.

And the outcome is skin Anhui Medical genetics research team published within one year of the second study results. Early this year, the team also used genome-wide association analysis (GWAS) method, in our first study found that psoriasis susceptibility genes. Currently, the team is analyzing genome-wide association study of leprosy, vitiligo and atopic dermatitis and other common skin disorders carried out.

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